Human-Computer Interaction and games set a new domain in understanding people’s motivations in gaming, behavioral implications of game play, game adaptation to player preferences and needs for increased engaging experiences in the context of HCI serious games. When the latter relate with people’s health status, they can become a part of their daily life as assistive health status monitoring/enhancement systems. Co-designing HCI-SGs can be seen as a combination of art and science that involves a meticulous collaborative process. The design elements (...) in assistive HCI-SGs for Parkinson’s Disease patients, in particular, are explored in the present work. Within this context, the Game-Based Learning design framework is adopted here and its main game-design parameters are explored for the Exergames, Dietarygames, Emotional games, Handwriting games, and Voice games design, drawn from the PD-related i-PROGNOSIS Personalized Game Suite holistic approach. Two main data sources were involved in the study. In particular, the first one includes qualitative data from semi-structured interviews, involving 10 PD patients and four clinicians in the co-creation process of the game design, whereas the second one relates with data from an online questionnaire addressed by 104 participants spanning the whole related spectrum, i.e., PD patients, physicians, software/game developers. Linear regression analysis was employed to identify an adapted GBL framework with the most significant game-design parameters, which efficiently predict the transferability of the PGS beneficial effect to real-life, addressing functional PD symptoms. The findings of this work can assist HCI-SG designers for designing PD-related HCI-SGs, as the most significant game-design factors were identified, in terms of adding value to the role of HCI-SGs in increasing PD patients’ quality of life, optimizing the interaction with personalized HCI-SGs and, hence, fostering a collaborative human-computer symbiosis. (shrink)

A protein kinase cascade is involved in the action of some mitogens. The cascade begins with receptor tyrosine kinase activation by growth factors. The resulting signal is transmitted into cells via phospholipid metabolism which produces a variety of second messengers and by intracellular protein kinase activation. The signal is then propagated and disseminated via a network of other proteln kinases and protein phosphatases. Recent research suggests that ribosomal protein S6 kinase and casein kinase II are two important elements in the (...) kinase cascade that leads to the initiation of growth. The nature and some properties of these hitherto lesser known enzymes is considered. (shrink)

The frequency and temperature dependences of the ac conductivity and dielectric constant of the V 2 O 5 -MnO-TeO 2 system, containing two transition-metal ions, have been measured. The dc conductivity † dc measured in the high-temperature range decreases with addition of the oxide MnO. This is considered to be due to the formation of bonds such as V--O--Mn and Mn--O--Mn in the glass. The conductivity arises mainly from polaron hopping between V 4+ and V 5+ ions. It is found (...) that a mechanism of adiabatic small-polaron hopping is the most appropriate conduction model for these glasses. This is in sharp contrast with the behaviour of the Mn-free V 2 O 5 -TeO 2 glass, in which non-adiabatic hopping takes place. High-temperature conductivity data satisfy Mott's small-polaron hopping model and also a model proposed by Schnakenberg in 1968. A power-law behaviour † ac = A y s , with s < 1) is well exhibited by the ac conductivity † ac data of these glasses. Analysis of dielectric data indicates a Debye-type relaxation behaviour with a distribution of relaxation times. The MnO-concentration-dependent † ac data follow an overlapping large-polaron tunnelling model over the entire range of temperatures studied. The estimated model parameters are reasonable and consistent with changes in composition. (shrink)

“What is it that agitates you, my dear Victor? What is it you fear?” -/- “The monster now becomes more vengeful. He murders Victor’s friend Henry Clerval and his wife Elizabeth on the night of her wedding to Victor, and Victor sets out in pursuit of the friend across the icy Artic regions. The monster is always ahead of him, leaving tell tale marks behind and tantalizing his creator. Victor meets with his death in the pursuit of the monster he (...) had created with a noble objective.” [ http://philpapers.org/profile/112741] . (shrink)

A complete self analysis on portrait of different dimensions through human characters in the society still...

[ https://plus.google.com/108060242686103906748/posts/cwvdB6mK3J6 ]"As Literature germinates within me, my words are-“Literature is something, that I need to be acclaimed for, I need to know more...it’s my life that has given me birth, my way of thoughts that I am visualizing in the perspective of all dimensions, my frailties, my faults...my every comprehensive discussion even after my death, my spiritualism, my haunting towards the ecology of the cosmic world, and the way that I have brought up at my elbows to enhance myself (...) more in the bloom of dissolved doomed tragedy of a human life! It is indeed ravenous…but we the beings to run through this midst of life, as I need to pace up with at every inception and the idealistic phenomenal moments…!”. . (http://philpapers.org/profile/112741.). (shrink)

[ https://plus.google.com/108060242686103906748/posts/cwvdB6mK3J6 ] The phenomenal description on own thoughts regard me to describe Coleridge, along with William Wordsworth, was instrumental in initiating a poetic revolution in the early nineteenth century which is known as the Romantic Movement. Coleridge invokes the Divine Spirit that blows upon the wild Harp of Time. Time is like the stringed musical instrument on which the Spirit produces sweet harmonious melodies. Coleridge is perhaps best known for his haunting ballad Rime of Ancient Mariner, the dream-like Kubla (...) Khan and the unfinished Christabel, but he wrote several other smaller poems, quite remarkable for their imaginative power. (Edited with own analysis)…[http://philpapers.org/profile/112741] http://www.academia.edu/18834746/LITERATURE_I_DO-_THE_ROMANTICS_AND_SUBJECTIVITY_SAMUEL_TAYLOR_COLER IDGE. (shrink)

THE IMMORTAL FLY: ETERNAL WHISPERS. WHO IS SHE? Author: Rituparna Ray Chaudhuri. Hello, Recently my book named, ‘The Immortal Fly: Eternal Whispers : Based On True Events of a Family' been published from Partridge (USA) In Association with Penguin Random House (UK) and achieved a separate Google identity. -/- As being # the author of the book, I thought to define self in the book what is definition of 'Depression'. I wanted to explain self in many ways, but the (...) best quotation appeared to me : “My life will end someday, but it will end at my convenience.’’ -/- ***** I am missing "her". By now, years passed without 'her' . Even though, unlike before, everything is becoming to be more scattered, gloomy and desolate. She is no-where whom I share my feelings. Even now, when I do close my eyes, I can visualize the same that I had left years since on 7th February, 2019 at 8.20 A.M. in the hospital struggling a continuous period of fifty days : on the fifty one day, my father said, ”The End of our Fifty Years relationship has been completed with the Fifty Days”….’Whoever’ she was to others , but she is our legend…To me, she is ‘My Ma’. -/- The story could begin, 'I failed preciously on success of my life.' Simplicity, Innocence, Belief, Faith and Personality met unknowingly with filthy waves skillfully immersed in Betray, Sorcery, Jealousy, Greediness, Revenge, Lie... ‘’ ******* The Daughter writes, “I had asked Ma many times, but her ‘impenetrable personality’ and dynamic words to everyone with a tinge of smile as reflected on her face, she was reluctant to continue her conversation with me. I had thought, hence, I must not be indefinite on my spoken words. Who shall I blame!” Based on true story of a family came from South Calcutta (India) to a suburb, on staying at home of the Daughter’s maternal grandmother’s house, this book reveals in facts and true events how Destiny had unknowingly ‘further’ played an abominable role to Fate of The Daughter, when eventually one day on 7th February, 2019 everything was finished within 8.20A.M. The Daughter is, therefore, left alone on terrestrial with immortal words as written in her Diary, ‘Eternal Whispers’: “My words to self that I am to fulfill my Ma’s - wish. ’’ ‘’ -/- • Keywords: 1. Diary and True Events 2. The Chaotic Society 3. Fatality 4. Of A-Family 5. Science , Philosophy and Literature 6. Severe Depression 7. Medical Journey. -/- The Alternative Title of the Book: The Greatest Mistake or Fortune:: The book is mainly carrying with intense words of a journey of the relationship between a Mother with her Daughter has left readers in an abrupt situation where ,perhaps, I can define "Man is the innocent creature with 'his' personality under circumstances..." -/- . (shrink)

"Then to this earthen Bowl did I adjourn My Lip the secret Well of Life to learn: And Lip to Lip it murmur'd-"While you live Drink!-for once dead you never shall return." " [http://philpapers.org/profile/112741] .

"My boat was moored beside an old bathing 'ghat' of the river, almost in ruins. The sun had set,"...https://youtu.be/VAhd2GNf1js. (http://philpapers.org/profile/112741).

( http://philpapers.org/profile/112741 )"Let generation know to procure the love, the concept, knowledge and ideas with thoughts they are acquiring on versatile English Language, instead of making themselves to be felt dealing with only burden." -/- I too realize, -/- "Literature is not merely going through a book, It is the moment of definition of per feeling that : I am acquiring through an imagery.".

“Marlowe wrote Edward The Second in 1590. He found a suitable tragic theme in the Holinshed’s account of Edward II’s reign though it was not a promising dramatic material from the chronological point of view as the events were disjointed and uninspiring disastrous. Improper coordinates of the sources has left its mark on Marlowe’s play, nevertheless, this is his most finished and satisfactory of plays…Edward The Second can surely be regarded as Marlowe’s finest technical achievement.” (Edited, Dr. S. Sen…).

"Let you see, whether it can help you- on topic of discussion..I cannot claim I am right, but I can suggest you.." LET PEOPLE DECIDE ON THE LANGUAGE, ON TOPIC OF DISCUSSION. ( http://philpapers.org/profile/112741 ).

"Men have died from time to time, and worms have eaten them, but not for love."Satyajit Ray Wikipedia The Free Encyclopedia 2015 .

(http://philpapers.org/profile/112741 ) [https://plus.google.com/108060242686103906748/posts/cwvdB6mK3J6 ] "Let generation know to procure the love, the concept, knowledge and ideas with thoughts they are acquiring on versatile English Language, instead of making themselves to be felt dealing with only burden." -/- I too realize, -/- "Literature is not merely going through a book, It is the moment of definition of per feeling that : I am acquiring through an imagery.".

"Who can tell us more about a man's character than his wife? Shakespeare allows Lady Macbeth to explain her husband's character as she understands it, and although she cannot see the "whole" truth, she tells us a great deal about Macbeth...." http://philpapers.org/profile/112741.

This book shows, "Nothing is permanent in this World" consisting of true events in span of life when matches with Classical Literature of reality against illusions..

The poem, has also highlighted the theme of isolation. The Darkling Thrush is the symbol of perseverance. Men at times is all by himself. There is none around. The frail, gaunt, aged , weather-beaten bird has stood against all odds. There is an air of self doubt and the poet is in a dilemma how to welcome the advent of a new era. It has endured all the odds of time and is happy today singing its joyful song.

"ON DEMAND OF A PUBLISHING HOUSE IN GERMANY, I WAS ASKED TO WRITE ON SCIENTIFIC METHODS THAT I HAD imbibed ON WRITING THE DOCUMENT" [Thanks to accept my work Christopher Marlowe's Edward The Second from Presidency College,Kolkata of interest to international audience] .

In spite of an overwhelming importance of business groups in the economic development of many countries, systematic inquiry on how the BGs and their affiliated firms approach and contribute to shared value creation and sustainable development is rare. In this paper we address this research gap by investigating two related questions—do BG-affiliated firms differ from non-BG firms in their corporate sustainability strategy and how does BG affiliation influence the relationship between stock of fungible resources and CSS of firms? Drawing from (...) the BG literature we theorize that BG-affiliated firms tend to adopt of both environmental and social sustainability strategies more than non-BG firms. We also argue that although according to resource-based view, the stock of fungible resources of firms positively influences CSS, BG affiliation negatively moderates the relationship between stock of fungible resources and CSS of firms. Stock of fungible resources matters less for BG-affiliated firms in undertaking CSS as they have access to resources of the BG network. We test our theoretical predictions using a proprietary data set of 163 Indian publicly listed firms, out of which 76 are BG-affiliated firms belonging to 74 BGs. The data for corporate environmental and social sustainability strategies have been obtained by administering a survey instrument among the top level executives of the participating firms. We find support for our theoretical predictions that signify that BGs and their affiliates make important contributions to shared value creation and sustainable development in emerging economies like India. (shrink)

'When Macbeth comes from the murder of Duncan, his hands are covered in King's blood; he looks at them, and feels that all the waters in the ocean cannot wash away the blood, but that- "this my hand will rather The multitudinous seas incarnadine, Making the green one red.,"... -/- (http://philpapers.org/profile/112741 ).

"Romanticism, when attains a fullness of complexity..there occurs of the supernatural unique". http://philpapers.org/profile/112741.

“Three poets in three distant ages born Greece, Italy and England did adorn; The first in loftiness of thought surpassed. The second in majesty; in both the last.” (http://philpapers.org/profile/112741).

To read Literature by Generation today in majority, is not to pass on the subject only, rather more than this know what 'you' are learning.. ( http://philpapers.org/profile/112741 ).

Its oft I had been asked by students and many of others of the given topic. What I personally felt be its answer, referring obviously standard books, I answered my seekers including also analyzing myself many times just twelve lines of the opening scene, which is in fact, later I thought, is containing a very ‘partial fulfillment’ of the conversation among the witches- perhaps that figures out the destiny of a mortal being, destiny of our tragic hero, full of “profound- (...) mature -complexity of human materialistic nature’’. ( http://philpapers.org/profile/112741 ). (shrink)

It is believed to me 'Teaching is also learning'. So do on self-development across Creativity based on Syllabus of Class IX and X of ICSE Board, I go on with my students.

"Rather than bookish, it is much enjoyable to create and evaluate something from own centralizing the facts and thoughts of the contents only pervaded in the book.

The book is written on purpose of Indian Academy for higher classes on English and British Literature. As personally found being a teacher that majority of students are incapable on setting and developing an answer on context of the chapter. It is hurt to say the sweetness of Classic Literature is exactly not teaching properly at Indian Academy on English and British Stories. Students , concerning at my place on context of the aforesaid book, only are gulping in India the (...) matter rather to understand the history on Literature. (shrink)

Brief: Analysis on English and British Literature widely along-with creative genre, on using different styles of linguistic capability at different types of Essays, reflected now on recent book 'The Revolt in the Desert (Journey on English Literature from India to USA).

This is my first book from Partridge International In Association with Penguin Random House in 2018. I wanted to enrich self through my creativity on selected topics as far as a Google Scholar.

"The theory of Darwin was improved upon by Lamarck. He laid down the principle that living organisms change because they want to. Lamarck , while making this statement, actually, introduced the Element of Mind in the universe. He observed that every cell or unit of life has a will, a purpose, a design and a hope. In other words, he came to the conclusion that everything has a soul. In this regard, there was a sort of conflict between the believers (...) in Darwinian-ism and Lamarck-ism. Shaw supported the views of Lamarck."..... -/- ( http://philpapers.org/profile/112741 ). (shrink)

(http://philpapers.org/profile/112741 )[http://www.academia.edu/7765592 ] :"When Shakespeare was writing 'The Merchant of Venice', most people believed that the sun went round the earth. They were taught that this was a divinely ordered scheme of things, and that -in England- God had instituted a Church and ordained a Monarchy for the right government of the land and the populace. 'The past is a foreign country; they do things differently there.'- L.P.Hartley. ".

Connected vehicle fleets have formed significant component of industrial internet of things scenarios as part of Industry 4.0 worldwide. The number of vehicles in these fleets has grown at a steady pace. The vehicles monitoring with machine learning algorithms has significantly improved maintenance activities. Predictive maintenance potential has increased where machines are controlled through networked smart devices. Here, benefits are accrued considering uptimes optimization. This has resulted in reduction of associated time and labor costs. It has also provided significant increase (...) in cost benefit ratios. Considering vehicle fault trends in this research predictive maintenance problem is addressed through hybrid deep learning-based ensemble method (HDLEM). The ensemble framework which acts as predictive analytics engine comprises of three deep learning algorithms viz modified cox proportional hazard deep learning (MCoxPHDL), modified deep learning embedded semi supervised learning (MDLeSSL) and merged LSTM (MLSTM) networks. Both sensor as well as historical maintenance data are collected and prepared using benchmarking methods for HDLEM training and testing. Here, times between failures (TBF) modeling and prediction on multi-source data are successfully achieved. The results obtained are compared with stated deep learning models. This ensemble framework offers great potential towards achieving more profitable, efficient and sustainable vehicle fleet management solutions. This helps better telematics data implementation which ensures preventative management towards desired solution. The ensemble method's superiority is highlighted through several experimental results. (shrink)

Over 100 million Americans suffer from chronic pain, which causes more disability than any other medical condition in the United States at a cost of $560–$635 billion per year. Opioid analgesics are frequently used to treat CP. However, long term use of opioids can cause brain changes such as opioid-induced hyperalgesia that, over time, increase pain sensation. Also, opioids fail to treat complex psychological factors that worsen pain-related disability, including beliefs about and emotional responses to pain. Cognitive behavioral therapy can (...) be efficacious for CP. However, CBT generally does not focus on important factors needed for long-term functional improvement, including attainment of personal goals and the psychological flexibility to choose responses to pain. Acceptance and Commitment Therapy has been recognized as an effective, non-pharmacologic treatment for a variety of CP conditions. However, little is known about the neurologic mechanisms underlying ACT. We conducted an ACT intervention in women with chronic musculoskeletal pain. Functional magnetic resonance imaging data were collected pre- and post-ACT, and changes in functional connectivity were measured using Network-Based Statistics. Behavioral outcomes were measured using validated assessments such as the Acceptance and Action Questionnaire, the Chronic Pain Acceptance Questionnaire, the Center for Epidemiologic Studies Depression Scale, and the NIH Toolbox Neuro-QoLTM scales. Results suggest that, following the 4-week ACT intervention, participants exhibited reductions in brain activation within and between key networks including self-reflection, emotion, and cognitive control. These changes in connectivity strength were correlated with changes in behavioral outcomes including decreased depression and pain interference, and increased participation in social roles. This study is one of the first to demonstrate that improved function across the DMN, SN, and FPN may drive the positive outcomes associated with ACT. This study contributes to the emerging evidence supporting the use of neurophysiological indices to characterize treatment effects of alternative and complementary mind-body therapies. (shrink)

Mitigating response distortion in answers to sensitive questions is an important issue for business ethics researchers. Sensitive questions may be asked in surveys related to business ethics, and respondents may intend to avoid exposing sensitive aspects of their character by answering such questions dishonestly, resulting in response distortion. Previous studies have provided evidence that a surveying procedure called the randomized response technique is useful for mitigating such distortion. However, previous studies have mainly applied the RRT to individual dichotomous questions in (...) face-to-face survey settings. In this study, we focus on behavioral research examining the relationships between latent variables, which are unobserved variables measured by multiple items on Likert or bipolar scales. To demonstrate how the RRT can be applied to obtain valid answers from respondents answering a self-administered online questionnaire with Likert and bipolar scales, we build a behavioral model to study the effect of punishment severity on employees’ attitudes toward misuse of information systems resources in the workplace, which in turn influence misuse behavior. The survey findings meet our expectations. The respondents are generally more willing to disclose sensitive data about their attitudes and actual behavior related to misuse when the RRT is implemented. The RRT’s implications for causal modeling and the advantages and challenges of its use in online environments are also discussed. (shrink)

We propose a novel edge detector in the presence of Gaussian noise with the use of proximal support vector machine (PSVM). The edges of a noisy image are detected using a two-stage architecture: smoothing of image is first performed using regularized anisotropic diffusion, followed by the classification using PSVM, termed as regularized anisotropic diffusion-based PSVM (RAD-PSVM) method. In this process, a feature vector is formed for a pixel using the denoised coefficient’s class and the local orientations to detect edges in (...) all possible directions in images. From the experiments, conducted on both synthetic and benchmark images, it is observed that our RAD-PSVM approach outperforms the other state-of-the-art edge detection approaches, both qualitatively and quantitatively. (shrink)